Madness is heading toward a logical and possibly titanic conclusion: All four No. 1 seeds made it to the men’s Final Four. First, resilient Florida is underway against relentless Auburn. Later, Cooper Flagg and Duke take on Houston at 8:49 p.

What are Final Four odds now? What to know about Houston Cougars vs Duke Blue Devils point spread, moneyline, over/under for March Madness betting.

No. 1 Duke, with one of the country’s best players, Cooper Flagg, will face No. 1 Houston for a chance to play for the NCAA title. The Blue Devils have not trailed in any of this year’s March Madness games, but none of their opponents have put significant pressure on the team the way Houston’s defense likely will.