What is the ideal antibody affinity you need? What is the final application of your project? Do you have any timeline or budget constraints? These are some of the parameters you may have to consider ...

Reviewed by Michael Greenwood, M.Sc. In phage-display, a gene encoding the surface protein of a bacteriophage is replaced with a gene encoding a novel protein. The technique can be used in drug ...

With a phage-display library derived from prostate-cancer tissue, we developed and used phage protein microarrays to analyze serum samples from 119 patients with prostate cancer and 138 controls, with ...

Recent advances in phage display for molecular evolution incorporate deep sequencing to enable greater library coverage. However, severe gaps and limitations associated with next generation sequencing ...

Mapping the individual amino acids where antibodies bind (epitopes) to target viral proteins (antigens) is crucial to predicting how target proteins may evolve to escape antibody binding, improve ...

Chimeric proteins combine multiple polypeptides that are not normally covalently linked into a single molecular entity in which each functional domain contributes to overall activity. They are ...

Techniques that put natural evolution on fast-forward to build new proteins in the lab have earned three scientists this year’s Nobel Prize in chemistry. Frances Arnold of Caltech won for her method ...