A defining feature of Alzheimer's disease is the abnormal, sustained accumulation of protein aggregates such as tau inside brain cells, which disrupts the cells' normal functions. As time passes, ...

Suggested Citation: "5 In Vitro Alternatives to Animal Models." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of ...

Typically, bone marrow research relies heavily on animal models and oversimplified cell cultures in the laboratory. Now, researchers from the Department of Biomedicine at the University of Basel and ...

Researchers at LSU’s Pennington Biomedical Research Center have developed and validated a new genetic animal model that gives ...

Researchers have developed a vascularized organoid model of hormone secreting cells in the pancreas. The advance promises to improve diabetes research and cell-based therapies. Researchers led by ...

Medical researchers have used animals, particularly mice, to mimic disease and study biological phenomena. The origin of mice as a standard model system for scientific research can extend back to the ...

Scientists have created the first bioengineered bone marrow model that can support the type of human stem cells that are crucial for bone marrow transplants and in vitro study work. LT-HSCs are vital ...

Researchers at Helmholtz Munich and the Technical University of Munich (TUM) have developed Nicheformer, the first large-scale foundation model that integrates single-cell analysis with spatial ...