While research has uncovered many details about how blood cells function within bone marrow, the work of other cells existing in that space has remained a relative mystery. Now, researchers from the ...

Using single-cell RNA sequencing analysis of bone-colonizing tumour cells and in vivo screening, lymphotoxin-β (LTβ) was identified as a key factor promoting bone colonization and outgrowth of breast ...

Tooth loss and bone degeneration are problems that modern medicine still struggles to fix. Data from the National Bone Health Policy Institute shows that 10 million Americans over the age of 50 have ...

Over the years, legislation has gradually angled to replace or reduce the use of animals in scientific research. In this context, establishing more representative in vitro models of bone development ...

An illustration of bone and bone marrow development. During the process, osteoclasts (cells in blue) expand the marrow cavity by absorbing and removing unnecessary bone. In this study, the team found ...

Our body’s “blood factory” consists of specialized tissue made up of bone cells, blood vessels, nerves and other cell types. Now, researchers have succeeded for the first time in recreating this ...

Estrogen plays an important role in keeping bones healthy. Now, researchers investigated how membrane-initiated estrogen receptor alpha (mERα) signaling in specific cell types of female mice affects ...