While 50%-80% of PPI prescriptions are unjustified, particularly for unnecessary nonsteroidal anti-inflammatory drug (NSAID)-related ulcer prophylaxis, PPIs remain underprescribed for patients at risk ...

Patients in the highest-exposure group, ie, those with more than 385 defined daily doses of PPIs, have an 83% higher risk for gastric neuroendocrine tumors than nonusers.

A tablet that tames heartburn can feel like a miracle. For many, a Proton Pump Inhibitor (PPI) ends the nightly burn and restores sleep. The trouble begins when that relief becomes routine, taken ...

Proton pump inhibitors (PPIs) are medicines commonly prescribed to treat acid-related digestive problems, including gastroesophageal reflux disease (or GERD). As of 2011, up to 1 in 5 older adults ...

Chronic proton pump inhibitor use was linked to worse trabecular bone quality and bone mineral density among men but not women. Among men, chronic proton pump inhibitor (PPI) use is associated with ...

Patients who used proton pump inhibitors were more likely than non-users to die from any cause. Cancer patients receiving immune checkpoint inhibitor (ICI) therapy may experience more severe toxicity ...