Over the past two decades, researchers have learned that DNA inside the cell nucleus naturally folds into a network of ...

Gene therapy holds the promise of preventing and curing disease by manipulating gene expression within a patient's cells. However, to be effective, the new gene must make it into a cell's nucleus. The ...

In 1869, Swiss scientist Friedrich Miescher isolated a mysterious substance from cell nuclei—an overlooked finding that would ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal ...

Scientists have recently been learning more about the importance of small bits of circular genetic material known as extrachromosomal DNA (ecDNA). These little circles of DNA can hitch a ride with ...

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by ...

A new study shows that cancer damages its own DNA by pushing key genes to work too hard. Researchers found that the most ...

Researchers at the School of Biological Sciences of The University of Hong Kong (HKU) have uncovered how eukaryotic cells can ...

As people age, their immune systems deteriorate. This makes them more susceptible to infections and can mean that vaccines ...

Overcoming tumor resistance to chemotherapy drugs has long been a challenge for oncology clinicians and researchers. Now, a new study suggests that blocking a key protein, p300, may force damaged ...