Telomeres — the protective caps at the ends of chromosomes — function like molecular clocks, shortening as cells divide and age. When they become too short, cells stop replicating, accelerating aging ...

Rare telomere and non-telomere genetic variants significantly affect survival in IPF patients, with non-additive effects on common risk variants. Polygenic risk scores (PRS-IPF) may play a crucial ...

Sequencing nearly half a million genomes, researchers show that most additive genetic influences on height, lipids, and other complex traits are now directly measurable, while pinpointing ultra-rare ...

An estimated 3 million Americans have an inflammatory bowel disease (IBD) such as Crohn's disease or ulcerative colitis. But ...

Genetic research uncovers a continuum between diabetes forms, offering insights for precision medicine. Study: Rare variant analyses in 51,256 type 2 diabetes cases and 370,487 controls reveal the ...

CAMBRIDGE, MA -- A new study from MIT neuroscientists reveals how rare variants of a gene called ABCA7 may contribute to the development of Alzheimer’s in some of the people who carry it.

Whether we are predisposed to particular diseases may depend to a large extent on variations in our genomes, but the influence on the presentation of certain pathological traits of genetic variants ...

A novel risk locus at 1q21.2 was identified, with the lead variant near MCL1, a regulator of apoptosis, showing a protective effect. The study revealed a genetic correlation of 0.39 between IPF and ...

People with rare genetic variants that are linked to Parkinson’s disease and other neurodegenerative disorders have a higher risk for developing amyotrophic lateral sclerosis (ALS), also called Lou ...

A novel genetic variant may be a driving force behind the development of metabolic dysfunction–associated steatotic liver disease (MASLD) in some cases, according to researchers at the Mayo Clinic in ...