When it comes to identifying cancer-driving mutations, research has focused almost exclusively on understanding how mutations in the coding region of genes may alter a protein’s function to promote ...

A study by IRB Barcelona reveals that transfer RNA (tRNA) genes accumulate mutations at a frequency up to nine times higher ...

Humans have about 3 billion DNA bases in their genetic makeup. However, most of it does not encode for protein.

Inocras and the Broad Institute analyzed 8,000+ TCGA cancer genomes to uncover new drivers and create a harmonized dataset ...

Despite progress in defining functional elements of noncoding DNA, it is still not fully understood. Researchers, using an experiment that elucidated the function of tens of thousands of noncoding ...

Researchers at Uppsala University have developed a new method to identify conserved noncoding mutations in the genome that may play a driving role in medulloblastoma brain tumors in children. The ...

In a recent study published in Nature, researchers in the United States aggregated and processed 76,156 human genomes to construct a genomic constraint map named "genomic non-coding constraint of ...

Almost 1,500 genes have been implicated in intellectual disabilities; yet for most people with such disabilities, genetic causes remain unknown. Perhaps this is in part because geneticists have been ...

Learn how small mutations in non-coding DNA can alter sex development in rodents.

The ability of different genetic variants—changes to one or more building blocks of DNA—to cause disease, and to what extent, has historically been opaque. Geneticist and Crick group leader Greg ...