Classical dendritic cells (cDCs) are essential for immune responses and differentiate from hematopoietic stem cells via intermediate progenitors, such as monocyte–DC progenitors (MDPs) and common DC ...

A recent study has shed light on the transcriptional regulatory mechanisms of Penicillium expansum, the fungal culprit behind blue mold disease in fruits. By mapping chromatin accessibility at ...

In the early 1980s, David Gilmour, now an emeritus biochemistry and molecular biology professor at Pennsylvania State University, joined the laboratory of geneticist and biochemist John Lis as a ...

A new study on dogs found that chromatin's spatial structure has a significant role in the evolution of social behavior. Chromatin, the compact form of DNA, not only packages genetic material but also ...

This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...

• Condensins are best known for their role in shaping chromosomes. Other functions such as organizing interphase chromatin and transcriptional control have been reported in yeasts and animals, but ...

Schizophrenia is a severe neuropsychiatric disorder characterized by hallucinations, false beliefs about oneself or the world ...

This includes the labeling of the dCas9 protein, engineering of sgRNA, and the use of dCas9 orthologs from different bacterial species. CRISPR, clustered regularly interspaced short palindromic ...

Epigenetics plays a critical role in human health by regulating gene expression without the direct modification of DNA sequence. Aberrant epigenetic modifications mediated by changes in DNA and ...