Apparently balanced reciprocal translocations are one of the most common genetic causes of male infertility. The commonly accepted underlying pathophysiological mechanism is that they impair meiosis ...

Reciprocal translocations are one of the most common structural chromosome abnormalities in our species and are present in one in 500 unselected newborns studied with a moderate level of banding. 1 ...

Menkes disease (MD) is a recessive X-linked syndrome described by Menkes (1) more than 40 y ago. It is characterized by progressive cerebral and cerebellar degeneration, growth retardation, and ...

Translocation is a genetic abnormality in which part of a chromosome moves to another chromosome. Chromosomes are genetic structures within cells that hold genes. When translocation occurs, it causes ...

Leukemia is an umbrella term for multiple different cancers that form in the blood, one such member of the leukemia family being chronic myelogenous leukemia (CML). CML is caused by a chromosomal ...

Robertsonian translocation is the most common form of chromosomal translocation in humans. It means that two chromosomes, the structures that make up a person’s DNA, join together in an abnormal way.

MONGOLISM is usually the result of trisomy of a small acrocentric chromosome in Group 21–22 in the Denver Classification. This is generally referred to as 21-trisomy. These patients have a somatic ...